Diagnostic Efficacy of Unconjugated Plasma Metanephrines for the Detection of Pheochromocytoma

Plasma Free Metanephrines as Diagnostic Markers of Pheochromocytoma

Quantitative determination of catecholamines and their O-methyl metabolites plays an important role in the diagnosis of pheochromocytoma (PHEO) – adrenal medulla tumour. This kind of tumour synthesizes, stocks, metabolizes and mostly secretes catecholamines. For this reason it is possible to use elevated concentrations of catecholamines and their metabolic products from plasma and urine as diag...

Plasma Metanephrines in the Diagnosis of Pheochromocytoma

Plasma chromogranin A or urine fractionated metanephrines follow-up testing improves the diagnostic accuracy of plasma fractionated metanephrines for pheochromocytoma.

CONTEXT The initial diagnosis of pheochromocytoma relies on plasma fractionated metanephrines levels. Normal levels exclude pheochromocytoma, but positive tests have a low positive predictive value due to the disease's rarity. OBJECTIVES The objective of the study was to evaluate three approaches to distinguish between true-positive and false-positive tests: 1) increased cutoff for plasma fra...

Plasma metanephrines in the diagnosis of pheochromocytoma.

OBJECTIVE To examine whether tests for plasma metanephrines, the o-methylated metabolites of catecholamines, offer advantages for diagnosis of a pheochromocytoma over standard tests for plasma catecholamines or urinary metanephrines. DESIGN Cross-sectional study. SETTING 3 clinical specialist centers. PATIENTS 52 patients with a pheochromocytoma; 67 normotensive persons and 51 patients wi...

study of cohesive devices in the textbook of english for the students of apsychology by rastegarpour

this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...